What are some patient types that may benefit from YUPELRI® nebulized maintenance therapy?

Patients who experience ongoing COPD symptoms and have difficulties using handheld inhalers due to dexterity issues, cognitive decline, worsening symptoms, or other conditions may benefit from YUPELRI® nebulized maintenance therapy.

Why might a patient with dexterity issues prefer YUPELRI® nebulization?

Patients with dexterity challenges, such as those with hand tremors from conditions like osteoarthritis or Parkinson’s disease, may find it difficult to use a handheld inhaler effectively. YUPELRI® nebulization provides an easier, more consistent delivery method.

What is YUPELRI® used for?

YUPELRI® is a once-daily nebulized long-acting muscarinic antagonist (LAMA) indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD).

How often should YUPELRI® be taken?

YUPELRI® should be taken once daily using a standard jet nebulizer as prescribed by a healthcare provider.

Can YUPELRI® nebulization improve patient adherence to COPD treatment?

Yes, some patients may find YUPELRI® nebulization easier to use than handheld inhalers, which can improve adherence to COPD maintenance treatment.

Patient Types

Many of your patients with ongoing symptoms may be candidates for nebulized maintenance therapy

Susan is experiencing cognitive decline^*†

75 yrs GOLD Group E FEV₁ ~45% predicted

Symptoms

Shortness of breath, fatigue, and disrupted sleep becoming more common
Medication History

Handheld maintenance inhaler and nebulized rescue therapy
Treatment Goal

Caregiver expresses need for simplified delivery, requiring less hand-breath coordination

After hospitalization for an exacerbation, Susan’s husband is concerned that her mild dementia is making it difficult to properly coordinate her breath.

Making sure Susan takes her daily medicine properly can be a challenge—I wish she could use one type of device where she doesn't need to coordinate her breath.

– SUSAN’S HUSBAND AND CAREGIVER

^*Not an actual patient.

Nearly 1/3 of COPD patients have borderline or impaired cognitive functioning (N=301).^5-7†

^†On tests measuring psychomotor speed and executive control functioning.
^‡The relationship between patient conditions, device type, and medication efficacy has not been established.

Cognitive impairments can be a common barrier to correct inhaler device administration.^5,8‡

Helen has dexterity issues^*†

65 yrs GOLD Group E FEV₁ ~50% predicted

Symptoms

Presented to clinic with chronic cough and increased sputum production, leading to chest tightness
Medication History

Handheld LAMA once daily; nebulized LABA twice daily
Treatment Goal

Prefers nebulization and desires one type of delivery system

Helen experiences progressive hand tremors and stiffness resulting from comorbidities (osteoarthritis, Parkinson’s disease). This has made it increasingly difficult to take her inhaled medication. While in the hospital, she utilized a nebulized LAMA and found it easy to use.

I've been struggling with my hand tremors, and using my inhaler has become a real challenge. I prefer nebulization and desire one type of delivery system."

– HELEN

^*Not an actual patient.

80% of patients report at least one condition that may impede optimal device technique (N=499).⁸

Selected responses from an ACCP-developed, quantitative, web-based, descriptive, cross-sectional survey of 499 patients (mostly former smokers, 55-74 years old) with self-identified COPD in the US.

^†The relationship between patient conditions, device type, and medication efficacy has not been established.

Individual characteristics play an important role in shaping your patients’ treatment.^9†

Robert has osteoarthritis^*†

65 yrs GOLD Group E FEV₁ ~50% predicted

Symptoms

Worsening symptoms include morning cough and shortness of breath
Medication History

Handheld maintenance inhaler; nebulized rescue therapy
Treatment Goal

Seeks a different way to take his maintenance treatment so he can feel more confident in the delivery of his therapy

After developing osteoarthritis, Robert's poor hand-grip strength makes it difficult to use his current maintenance therapy to manage his worsening symptoms. He expresses concern with his ability to use his inhaler.

I try to use my inhalers every day like my doctor told me to, but it’s hard to use the inhaler properly. It feels like my symptoms are getting worse.

– ROBERT

^*Not an actual patient.

44% of COPD patients self-reported having arthritis (N=499).⁸

^†The relationship between patient conditions, device type, and medication efficacy has not been established.

Arthritis or other manual dexterity issues may prevent patients from using inhaler devices properly.^8†

Diane is experiencing worsening symptoms^*†

65 yrs GOLD Group B FEV₁ ~70% predicted

Symptoms

Worsening symptoms are cough, increased sputum production, and a lack of energy
Medication History

Nebulized short-acting bronchodilator
Treatment Goal

Prefers nebulization and desires reliable symptom control

Diane is comfortable taking her nebulized short acting bronchodilator medication for her COPD, but has been experiencing worsening symptoms since her last doctor's visit, including cough, increased sputum production, and a lack of energy.

I like taking my COPD medication through a nebulizer, but I am now taking my medicine more frequently, at 4 to 6 times a day. It's tough to do the things I used to do.

– DIANE

^*Not an actual patient.

Many COPD patients are undertreated, and over half do not receive the GOLD recommended maintenance medications (N=55,361).^10,11†

^†The relationship between patient conditions, device type, and medication efficacy has not been established.

Maria has impaired inspiratory flow^*†

61 yrs GOLD Group B FEV₁ ~73% predicted

Symptoms

Experiences exertional dyspnea on her daily walks
Medication History

Handheld maintenance inhaler; nebulized rescue therapy
Treatment Goal

Desires reliable symptom control

With impaired inspiratory flow, Maria is out of breath when she attempts her daily walk despite using her handheld maintenance inhaler every day. She's now relying on her nebulized rescue therapy more than ever, which worries her.

I use my maintenance inhaler every day, but I’m still out of breath when I walk. So I’ve been using my rescue medication a lot, which worries me.

– MARIA

^*Not an actual patient.

~19% of patients 60+ with advanced COPD have impaired inspiratory effort (N=213).^12†

^†Defined as lower than 60 L/min.
^‡The relationship between patient conditions, device type, and medication efficacy has not been established.

Inspiratory flow is one of many factors to consider when choosing a delivery device.^13‡

Ken is transitioning from hospital to home care^*†

65 yrs GOLD Group E FEV₁ ~50% predicted

Symptoms

Chronic nonproductive cough, shortness of breath, and wheezing at admission
Medication History

Preadmission: Using handheld maintenance and rescue inhalers

During admission: Stabilized and transitioned to nebulized maintenance and rescue therapies
Treatment Goal

Looking to maintain the symptom improvement achieved with nebulized maintenance and rescue therapies during admission

On handheld maintenance and rescue inhalers prior to being hospitalized for an acute exacerbation, Ken is now looking to maintain the symptom improvement he achieved with nebulized maintenance and rescue therapies during admission.

The nebulizer for my maintenance therapy that was given to me at the hospital improved my symptoms. I’d like to keep using the same device after I leave.

– KEN

^*Not an actual patient.

Only 6% of patients with severe COPD used their inhaler therapy regularly and with correct technique a majority of the time in the month following hospital discharge (N=179).^5†

^†The relationship between patient conditions, device type, and medication efficacy has not been established.

ACCP=American College of Chest Physicians; COPD=chronic obstructive pulmonary disease; FEV₁=forced expiratory volume; GOLD=Global Initiative for Chronic Obstructive Lung Disease; LAMA=long-acting muscarinic antagonist.

EXPLORE ADDITIONAL CONTENT

Benefits of Nebulization

Discover how nebulizers can serve as a practical and user-friendly choice for your patients.^3,4

Learn More

Optimizing Patient Conversations

Find out how to get the most out of conversations with your patients.

Learn More

This site is intended for US healthcare professionals.